Neuroprosthesis serves as communication aid for ALS patient for 7 years

ALS is een progressieve spierziekte

People with ALS face a poor prognosis. The disease progressively affects more muscles, eventually making movement, communication, and ultimately life itself impossible. In the final stage, a patient may develop Locked-In Syndrome, in which no form of communication is possible anymore.

The neuroprosthesis as a solution

To compensate for the progressive decline, researchers at UMC Utrecht are working on the development of neuroprostheses, also known as Brain-Computer Interfaces (BCIs). A neuroprosthesis consists of electrodes implanted in the brain that pick up signals. These signals are then translated via a computer connection into commands for operating a computer, such as a mouse click. This enables a patient to continue communicating even after the onset of Locked-In Syndrome.

How long does a neuroprosthesis work?

For the first time, the UMC Utrecht team conducted a long-term study on an ALS patient who received a neuroprosthesis. The study showed promising results. Mariska: “Our participant used the system independently for seven years, and for several of those years it was her only way of alerting her caregiver, both during the day and at night.” The device itself continued functioning well. Only when the disease had progressed to the point that the brain could no longer send strong signals did the neuroprosthesis stop being effective.

While the disease cannot be halted with a neuroprosthesis, the technology can still make a crucial difference in the quality of life and autonomy of people with ALS, even in later stages. “As long as the brain is able to send a message, the system works—and it can make a tremendous difference in the lives of these patients and their families,” says Mariska.

Neuroprostheses are becoming more accessible

The development of neuroprostheses is advancing rapidly, with significant investment being made. It is expected that in the coming years, these devices will become widely available and can be used to help people with severe communication impairments caused by ALS or other conditions. This is also reflected in the current edition of the New England Journal of Medicine, which features a second article on BCIs. “In that other study, a person in an earlier stage of ALS was able to communicate quickly and accurately using a BCI. This shows that BCIs can also be valuable for people with less severe impairments.”

Furthermore, (new) treatments that slow the progression of ALS are likely to extend the period in which a BCI can be useful.

“We are currently working on improved versions of the technology and hope to demonstrate its value as a communication tool in the daily lives of these patients in our new projects: CORTICOM, INTENSE, and INTRECOM,” Mariska concludes.

Source: UMC Utrecht