Research Princess Máxima Center on childhood cancer and genetic predisposition
Physician-researchers Jette Bakhuizen and Sebastian Bon are conducting research to improve diagnostics for genetic predisposition to childhood cancer. The results of these studies have led to changes in genetic testing policies. A video has also been made for children and parents explaining what genetic testing is and what the advantages and disadvantages are.
In DNA testing, we look at a child’s genetic material to see what changes have contributed to the development of cancer cells,’ explains Jette Bakhuizen. ‘We look at both tumor cells and healthy cells that reflect the child’s genetic predisposition. This helps not only to make an accurate diagnosis, but also to determine the best treatment.’
‘It is important to understand that DNA testing of normal cells can not only help the child with cancer, but also be of value to family members. If we find a hereditary predisposition, relatives can be monitored, which can help with early detection of cancer. This opens up possibilities for better treatments,’ says Sebastian Bon.
Jette Bakhuizen: ‘At diagnosis, only a limited number of cancer predisposition genes will be tested, only those that can really help in diagnosis and in choosing the right treatment. If the pediatric oncologist or parents have questions about genetic predisposition, a child can still be referred to the clinical geneticist. Because we believe it is important to investigate new forms of genetic predisposition in cancer with cancer, we will ask all children and parents for their permission to participate in scientific research about genetic predisposition.’
In the interactive video on genetic predisposition, Sebastian Bon explains genetic testing step by step. When is genetic testing done? What are the (dis)advantages? What are the possible consequences?
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