The Utrecht Science Park Foundation aims to add social and economic value to the regional economy. The Foundation strives to achieve this goal by encouraging and strengthening cooperation between knowledge institutions and innovative companies, developing alliances in the region, offering facilities to fledgling entrepreneurs, attracting business activity, improving facilities, promoting liveability, and raising Utrecht Science Park's profile as a business location for knowledge-intensive activity.

The Foundation's activities are centred around the key concepts of 'excellent hospitality, building and maintaining relationships and reputation' . Utrecht Science Park Foundation creates optimal preconditions for new and established businesses seeking to set up and expand operations at the park. The Foundation works to create job opportunities that closely reflect the Utrecht region's key knowledge areas. This strategy helps to generate sustainable regional jobs and offer all residents of the Utrecht region and the Netherlands as a whole opportunities for prosperity and development.

As of 2017, Jan Henk van der Velden is managing director of the Utrecht Science Park Foundation.

The Foundation has an independent Supervisory Board consisting of: 

• Peter den Oudsten - voorzitter
• Prof. dr. Arno Hoes, lid raad van bestuur UMC Utrecht
• Jan Bogerd MBA, voorzitter college van bestuur HU
• Ton Logtenberg PhD
• Margot van der Starre, vice voorzitter CvB UU